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Study shows frozen embryos are successful and show no increased risk of congenital malformations

An article in the UK newspaper The Telegraph discussed the issue of the use of frozen embryos for IVF treatments.

According to the article, the study analyzed more than 1,200 children born from a frozen embryo transfer over a ten-year span, finding that the babies born from frozen embryos had a higher birth weight and had no increased risk of congenital malformations.

Additional details on the study, as discussed in the article, are listed below by Kate Devlin, Medical Correspondent, at the annual meeting of ESHRE in Barcelona.
Babies from frozen embryos are born heavier than those from fresh embryos
Infants born from embryos which were frozen and then thawed before being implanted into a woman had a higher birth weight and were less likely to suffer abnormalities.
Fewer of the children were also twins or triplets.
Multiple births are known to increase the risk of complications as well as the danger to the mother.
More than 1,200 children born between 1995 and 2006 after frozen embryo replacement (FER) were studied and compared to 17,857 children born from "fresh" embryos.
Freezing embryos allows couples to have several In-Vitro Fertilisation (IVF) treatment cycles from the same egg collection, reducing the number of times that the ovaries are stimulated.
The eggs are placed in the womb three to five days after ovulation in exactly the same way as fresh embryos.
Multiple births accounted for 27.3 per cent of children born from fresh embryos, compared with 14.2 per cent when frozen embryos were used.
Babies from frozen embryos were on average 200 grams heavier on birth than those from fresh embryos, the findings presented at the annual meeting of the European Society of Human Reproduction and Embryology (Eshre) in Barcelona.
The proportion of low birth weight and pre-term FER children was significantly lower.
Dr Anja Pinborg, from the Copenhagen University Hospital Rigshospitalet, who led the study, said: "Most encouragingly, we found no increased risk of congenital malformations in the FER group; the rate in this group was 7.1 per cent compared to 8.8 per cent where fresh embryos had been used.
"We think the reason for the differences is probably positive selection of the embryos for frozen embryo replacement.
"Only the very top quality embryos survive the freezing and thawing process.
"And you only get pregnancies in patients with lots of good embryos to freeze."
Story from Telegraph News:


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