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October 2007 Archives

October 8, 2007

Orange County’s “Physicians Of Excellence” Award

Every year the orange county medical association and orange coast magazine select the area's "physicians of excellence." the elite annual award recognizes honorees based on merit and proficiency in the field of obstetrics and gynecology. Recipients were evaluated by physicians and acclaimed members of the medical community. I am honored to be selected as a ‘Physician of Excellence’ from amongst Orange County’s finest in the field of reproductive medicine.

Collaborative PGD Study by Drs. Werlin and Munné Et. Al to Be Presented At American Society of Reproductive Medicine Conference

I am very excited to tell you that a colleague of mine, internationally-recognized fertility researcher Dr. Santiago Munné, is presenting our collaborative study at the upcoming American Society of Reproductive Medicine (ASRM) Annual Conference. The study presents groundbreaking discoveries on the impact of Preimplantation Genetic Diagnosis (PGD) on live birth rates for women of advanced maternal age. The conference, held in Washington, D.C., is an assembly of leaders in the field of reproductive medicine from throughout North America and abroad.

Our study includes data which suggests that PGD can significantly increase the chance of pregnancy to term in multiple In Vitro Fertilization (IVF) programs, while also reducing the risk of miscarriage in women ages 38 to 42. Results also indicate that PGD is more effective in some IVF centers compared to others, which suggests that patient selection, follicular stimulation, culture system and biopsy may play important roles.

This study gives new hope to women of advanced maternal age who want to begin a family. PGD reduces the chance for spontaneous miscarriage and increases take-home baby rates.

PGD is a therapeutic, genetic testing tool that allows for the analysis and transfer of healthy embryos back into the uterus. The procedure has gained recognition for its ability to analyze the cells of a developing embryo via biopsy for genetic and chromosomal abnormalities.

The study included results from fertility clinics across the United States including Reprogenetics and the Institute for Reproductive Medicine and Science at Saint Barnabas, both in N.J.; Zouves Fertility Center, Coastal Fertility Medical Center, and The Center for Reproductive Medicine, located in Calif.; and Highland Park IVF Laboratory in Ill. Munné will present the study to attendees at the ASRM Conference on Wednesday, Oct. 17.

About Dr. Munné
Dr. Santiago Munné, an award-winning and internationally recognized leader in reproductive medicine research, is the director of Preimplantation Genetic Diagnosis at Reprogenetics, LLC. He is a member of the American Society for Reproductive Medicine and the American Society of Human Genetics and Alpha, an international organization for scientists in reproductive medicine. For more information, visit http://www.Reprogenetics.com.

About The American Society of Reproductive Medicine
The American Society for Reproductive Medicine, founded in 1944, is an organization of more than 8,000 physicians, researchers, nurses, technicians, and other professionals dedicated to advancing knowledge and expertise in reproductive biology. Affiliated societies include the Society for Assisted Reproductive Technology, the Society for Male Reproduction and Urology, the Society for Reproductive Endocrinology and Infertility, and the Society of Reproductive Surgeons. To learn more about the Annual ASRM Conference, please visit http://www.ASRM.org.

October 4, 2007

IVF technique enables pregnancy without multiple births, Stanford researchers find

A new study done by Stanford University has shown that a new IVF technique can help avoid multiple births in women older than 35. Below is an article discussing this study, please read and enjoy.

IVF technique enables pregnancy without multiple births, Stanford researchers find
October 02, 2007 - STANFORD, Calif. - An in vitro fertilization technique that can avoid multiple births appears to be effective for women older than 35, according to researchers at the Stanford University School of Medicine.

More than half the women in a retrospective study became pregnant after undergoing the procedure, called a single blastocyst transfer, which transferred just one embryo into the womb.

Nearly 60 percent of IVF procedures in the United States are performed on women older than 35, and the study's senior author, Amin Milki, MD, believes the findings are good news for those women who wish to become pregnant with just one child.

"Although these results represent a selected group of patients, we believe that they should serve as encouragement to patients and providers who are considering single blastocyst transfer in the older IVF population," Milki and his co-authors noted in the study, which was recently published online in the journal Fertility and Sterility.

During the transfer procedure, an embryo is bathed in a culture of nutrients for five days until it reaches a developmental landmark known as the blastocyst stage. At that point, doctors are able to determine which embryos are most likely to thrive long term; they then transfer the best-quality ones into a woman's uterus.

The American Society for Reproductive Medicine currently recommends that doctors transfer two or more embryos into women older than 35, in an effort to maximize a patient's chance of becoming pregnant. This practice can lead to twins or higher-order multiples - as well as subsequent health risks - but Milki said this doesn't stop most patients from undergoing the procedure.

"Many patients would prefer not to have two babies at once," said Milki, professor of obstetrics and gynecology and director of Stanford's IVF program. "But because the success rate is higher when multiple embryos are transferred, women are willing to take the gamble."

In recent years, many reproductive specialists - especially those in Europe - have embraced single embryo transfer as a way to prevent multiple gestations. And data now exist showing the procedure's effectiveness among women of younger reproductive age.

Scant data exist on single blastocyst transfer in women over 35, so Milki and his colleagues decided to review the outcomes of older patients who underwent the procedure at Stanford. Milki said the procedure had been offered to those women with good-quality embryos, and the patients who elected to have only one embryo transferred did so as a way to avoid twin pregnancy. He noted that half the patients already had one child and wanted just one more, while others hoped to avoid the health complications associated with carrying multiples.

After reviewing the data from 45 patients ranging in age from 35 to 43 (with a mean age of 37.3), Milki and his colleagues found that 28 patients (62.2 percent) conceived, and 23 (51.1 percent) had pregnancies that went beyond the first trimester. Milki called this an "excellent pregnancy rate" - especially considering that the national success rate of IVF procedures for women in this age group is around 25 percent. But he pointed out that the women in this study all had good-quality embryos and had a relatively good chance of becoming pregnant.

"This offers reassurance that a woman can still expect a good pregnancy rate without gambling with twins," said Milki. He added that the findings demonstrate a "clear role" for the procedure in older IVF patients, and he said Stanford's IVF program plans to continue offering the procedure as an option for patients.

Milki did caution that the findings are not applicable to every woman over the age of 35. For women with lower-quality embryos, transferring two or three embryos might be the better way to pursue a pregnancy.

Stanford University Medical Center

About October 2007

This page contains all entries posted to Dr. Werlin's Fertility World in October 2007. They are listed from oldest to newest.

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