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August 2007 Archives

August 29, 2007

New study shows 'Fat Eggs' Causes Infertility In Obese Women

I wanted to share an article I thought would be of interest to my readers. The article discusses a recent study completed by the University of Adelaide's Research Centre for Reproductive Health. The study found that a direct coloration between obesity and infertility. Enjoy the article.

August 27, 2007

'Fat Eggs' Causes Infertility In Obese Women
Science Daily — A University of Adelaide researcher has discovered scientific evidence that obesity is a key factor in infertility - because of how it affects women's eggs.

While obesity has long been thought to be a major factor in couples' inability to conceive, this is the first time the effects of obesity on the egg have been discovered.

The research findings - using female mice - have been made by PhD student Cadence Minge in the University of Adelaide's Research Centre for Reproductive Health.

Importantly, her research has also discovered a way to completely reverse the effects of obesity on mouse eggs, enabling afflicted eggs to develop into healthy embryos.

"Consuming a diet high in fat causes damage to eggs stored in female ovaries. As a result, when fertilised these eggs are not able to undergo normal, healthy development into embryos," Ms Minge says.

Ms Minge has discovered that a protein in the cells surrounding, supporting and nourishing the egg - called Peroxisome Proliferator-Activated Receptor gamma (PPAR?) - is the main reason behind diet-induced infertility.

"The behaviour of this protein helps to determine the way in which the ovaries sense and respond to fats," Ms Minge says.

"Being able to control this protein will be very important in the quest to reverse infertility caused by poor diets."

Ms Minge's research has found that when the protein is selectively targeted with the anti-diabetes drug rosiglitazone (marketed as Avandia by GlaxoSmithKline), the adverse effects of obesity on egg quality are completely reversed.

"The drug enables us to switch on the protein, thereby changing the way in which the ovaries sense and respond to fats. Embryo development rates are restored, and the cellular differentiation of the early embryo is improved. In the long-term these improvements can result in increased birth weight and fetal survival," Ms Minge says.

However, Ms Minge warns that rosiglitazone should not be seen as a "quick fix" for infertile women.

"The rosiglitazone findings are of great significance for scientists researching egg maturation within the ovary. But at this stage, the research findings have only been made in mice. Also, the drug itself can have possible harmful side-effects, and more research is needed to find other, safer ways of activating the protein," she says.

"With more research, if we can pinpoint critical cellular controls of egg quality, it may allow women to maximise their likelihood of healthy conception."

Ms Minge says her findings emphasise the importance of a healthy lifestyle for women interested in conceiving children naturally.

"Despite the wide-ranging recognised health risks associated with excessive body weight, Australia's waistline continues to expand. Currently, Australia is on par with heavyweight nations such as the US and the UK, with approximately 60% of Australian adults now overweight or obese," Ms Minge says.

"I hope that these findings encourage people to carefully consider the impact of lifestyle choices on longer-term quality of life."

Note: This story has been adapted from a news release issued by University of Adelaide.

August 22, 2007

Health Radio Network Interview

In a previous post, I mentioned a radio interview I was doing for Health Radio Network. The program was a great success and I had a wonderful time talking with host Melanie Cole about women’s health and fertility. For all of you that tuned in during the original airing, I hope you found the segment both informative and enjoyable.

To replay the broadcast or catch it for the first time, please visit:

August 13, 2007

Talk to Me on the HealthRadio.net Program

This Wednesday, August 15 from 12:30 – 1:00 pm PT, I will be a guest on HealthRadio.net, an online health news and interactive talk show.

For couples interested in learning more about general fertility issues running the gamut from “What encompasses infertility?” to “Is IVF or PGD right for me?” I invite you to listen in.

Listeners can tune into the show at: WWW.HEALTHRADIO.NET

About August 2007

This page contains all entries posted to Dr. Werlin's Fertility World in August 2007. They are listed from oldest to newest.

July 2007 is the previous archive.

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Many more can be found on the main index page or by looking through the archives.

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